Even if you're far from a fight you can still help from afar with Mega Inferno Bomb.
Slowing your enemies with Hexplosive Minefield makes it easier to land other abilities.
Knocking yourself over walls with Satchel Charge can be great when chasing after or escaping from enemies.
Don't step on Ziggs' mines! They'll slow you and make it much easier for him to hit you with his other abiltiies.
Many of Ziggs' abilities have long cooldowns. Try catching him just after he's used his abilities.
Ziggs' ultimate, Mega Inferno Bomb, deals more damage in the center of the explosion.