Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch is fragile. Work with teammates to focus on him when you're able to catch him out of Camouflage.
Spell Shields won't block the damage from Deadly Venom, but they will block the effects Twitch can trigger with it.
If you suspect Twitch has left the lane, let your teammates know that Twitch is ''MIA.''